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Barry M. Wise, Ph.D.

President, Eigenvector Research, Inc.

phone: (509)662-9213
e-mail: bmw@eigenvector.com

Education:

Ph.D. (Chemical Engineering), granted March, 1991. M.S. Chemical Engineering, 1987. B.S. Chemical Engineering and B.S. Chemistry, 1982. All degrees from University of Washington.

Experience:

January 1995 – present, President and Co-Founder, Eigenvector Research, Inc., a full service chemometrics research, consulting, training and software company.

  • Creator of PLS_Toolbox Advanced Chemometrics software for use with MATLAB®. Have directed the continued development of PLS_Toolbox and other software packages for process monitoring and hyperspectral image analysis along with the infrastructure for supporting thousands of users.
  • Creator of Eigenvector University, an annual week-long series of chemometrics courses typically attended by ~50 students and taught by ~8 instructors, now in its 15th edition. Have taught approximately 200 short courses in 15 countries attended by thousands of employees and students from over 250 corporations, research laboratories and universities. Have also developed online learning alternatives and webinar series.
  • Completed consulting projects in a wide variety of applications including development of analytical devices for medical applications, threat detection, environmental and process monitoring as well as fault detection systems for use in chemical and manufacturing processes.
  • Authored and co-authored more than 50 peer reviewed journal articles, in addition to several book chapters, patents, conference proceedings, etc. cited over 4100 times, h-index 34.
September-November, 2008, Visiting Researcher, Ecole Polytechnique Fédérale de Lausanne (EPFL), Automatic Control Laboratory, Lausanne, Switzerland. Research focuses on methods for updating multivariate calibration models.

April-May, 1999, United Kingdom Research Fellowship, University of Newcastle Upon Tyne. Project focused on application of multi-way models to batch process data.

September 1982 – December 1994, Senior Research Scientist, Battelle Pacific Northwest Laboratory, Richland Washington. Projects included: basic research on ion exchange and precipitation processes for decontaminating radioactive waste solutions and subsequent flowsheet development for these processes.

June 1991 – December 1995, Owner, Eigenvector Technologies. Development and sales of PLS_Toolbox for use with MATLAB.

May 1992 – May 1997, Adjunct Lecturer in Chemical Engineering, Washington State University. 

March – June 1991, Acting Assistant Professor, Dept. of Chem. Eng., University of Washington.

September 1985 – March 1991, Research Assistant, Dept. of Chem. Eng., University of Washington. Ph.D. dissertation: Adapting Multivariate Analysis for Monitoring and Modelling Dynamic Systems.

Research Interests:

All aspects of chemometrics, particularly the application of chemometric methods for chemical process analysis, monitoring and control. Also methods for use in medical diagnostic devices, chemical threat detection systems and hyperspectral image analysis. Recent work has focused on adapting and evaluating modern machine learning methods and artificial intelligence for use in chemical applications.

Other Interests:

The promotion of youth academics and athletics, especially alpine ski racing. United States Ski and Snowboard Level 3 Technical Delegate. Have officiated at over 300 alpine race events and volunteered at many more. Through Eigenvector, Sponsor of Mission Ridge Ski Team, Schweitzer Alpine Racing School and University of Colorado Ski Team. Active with Lake Chelan Valley Scholarship Foundation which provides scholarships for college undergraduate education for Chelan, Manson, Holden and Stehekin youth.

Honors and Awards:

  • 2001 Eastern Analytical Symposium Award for Achievements in Chemometrics (only recipient of the award from private industry)
  • 2002 Unilever R&D Vlaardingen (URDV) Author Award for Best Paper, “Canonical Partial Least Squares and Continuum Power Regression” with S. de Jong & N.L Ricker
  • 2012 Pacific Northwest Ski Association John Genoud Award for service as a race official
  • 2014 Mission Ridge Ski Team Hampton Award for service to the team
  • 2019 Herman Wold Medal in Gold “for Pioneering Achievements in Process Chemometrics and his extensive deep commitment to the development and proliferation of the field of chemometrics,” presented by the Swedish Chemical Society. (Only non-academic and only American to receive the award.)
  • 2019 Summer Fun Nationals Masters Skier of the Year for service as an official and as a competitor.

Conference Chairmanships:

  • 1994, Chair, First InterNational Chemometrics InterNet Conference, InCInC ’94, the first conference in the chemical sciences to utilize the World Wide Web.
  • 1995, Chair, Gordon Research Conference on Statistics in Chemistry and Chemical Engineering.
  • 1997, Chair, Three-way Methods in Chemistry and Psychology, TRICAP’97, Manson, WA.
  • 2002, Chair, Chemometrics in Analytical Chemistry, Seattle, WA.
  • 2018, Co-chair, International Association for Spectral Imaging, IASIM Conference, IASIM, Seattle, WA.

Board Positions:

  • 1996-present, Editorial Board, Journal of Chemometrics
  • 1996-2010, Editorial Board, Chemometrics and Intelligent Laboratory Systems
  • 1998-2008, Editorial Board, Critical Reviews in Analytical Chemistry
  • 2002-present, Board of Directors, Lake Chelan Valley Scholarship Foundation
  • 2009-2011, Board of Directors, Mission Ridge Ski Education Foundation
  • 2013-2017, Board of Directors, Pacific Northwest Ski Education Foundation

Languages:

English, Intermediate French. Working on 900+ day Duolingo streak.

Interviews:

J. Workman, Jr., “Advances in Chemometrics for the Analytical Sciences,” Spectroscopy, July 2019.

AZoM Editors, “Avoiding the Everyday Pitfalls of Chemometrics,” AZO Materials Insights from Industry, April 2019.

FOSS, “Chemometrics Q&A at FOSS World Headquarters,” FOSS, January 2013.

Publications:

B.M. Wise et. al., “PLS_Toolbox Advanced Chemometric Software for use with MATLAB,” Version 8.8, Eigenvector Research, Inc., Manson, WA, USA, December 2019.

B.M. Wise and J.M. Shaver, “Detection of cervical cancer from evoked tissue fluorescence images using 2- and 3-way methods,” SPIE Proceedings, February 2019.

W. Windig, B.M. Wise and M.R. Keenan, “The role of sparsity and the behavior for mixture data in homeopathic independent component analysis,” submitted, 2017.

B.M. Wise and R.T. Roginski, “Model Maintenance: the unrecognized cost in PAT and QbD,” Chemistry Today, Vol. 33(2), pps. 38-43, March/April, 2015.

B.M. Wise and R.T. Roginski, “A Calibration Model Maintenance Roadmap,” Proceedings of ADCHEM 2015, Whistler, BC, Canada, pps. 260-265,  June, 2015.

N. Gallagher, J.M. Shaver, R. Bishop, R.T. Roginski and B.M. Wise, “Decompositions using maximum signal factors,” J. Chemometrics, Vol. 28, no. 8, pps. 663-671, 2014.

B.M. Wise, N.B. Gallagher, R. Bro, J.M. Shaver, W. Windig, R.S. Koch and D. O’Sullivan, PLS_Toolbox 7.9 for use with MATLAB, Software, Eigenvector Research, Inc., Wenatchee, USA, October, 2014.

B. Rogers, J. Grate, B. Pearson, N. Gallagher, B. Wise, R. Whitten, and J. Adams, “Combined, solid-state molecular property and gamma spectrometers for CBRNE detection,” SPIE CBRNE Sensing XIV, Baltimore, MD, USA, April, 2013.

W. Windig, J.M. Shaver, M.R. Keenan and B.M. Wise, “Simplification of alternating least squares solutions with contrast enhancement,” Chemo. and Intell. Lab Sys, Vol. 117, pps. 159-168, 2012.

P. Gujral, M. Amrhein, R. Ergon, B.M. Wise and D. Bonvin, “On Multivariate Calibration with Unlabeled Data,” J. Chemometrics, Vol. 25, pps 456-465,  August, 2011.

J.W. Grate, M.H. Abraham and B.M. Wise, “Design and Information Content of Arrays of Sorption-Based Vapor Sensors Using Solubility Interactions and Linear Solvation Energy Relationships,” Chapter 9 in Computation Methods for Sensor Material Selection, M.A. Ryan, Editor, Springer, 2010.

P. Gujral, M. Amrhein, B.M. Wise and D. Bonvin, “Framework for explicit drift correction in spectroscopic calibration models,” J. Chemometrics, Vol. 24, pps 534-543, May, 2010.

D.B. Hibbert, P. Minkkinen, N.M. Faber and B.M. Wise, “IUPAC project: A glassary of concepts and terms in chemometrics, Analytica chimica acta, Vol. 6, pps. 3-5, 2009.

W. Windig, M.R. Keenan and B.M. Wise, “The effect of pre-processing of image data on self-modeling image analysis,” J. Chemometrics12(9), pps. 500-509, 2008.

F.A.R. Quijano, D. Marrow, B.M. Wise, and W.J. Goux., “Prediction of nucleating sequences from amyloidogenic propensities of tau-related peptides,” Biochemistry45(14), 4638-4652, 2006.

W. Windig, N.B. Gallagher, J.M. Shaver and B.M. Wise, “A New Approach for Interactive Self-Modeling Mixture Analysis,” Chemometr. Intell. Lab.77(1-2), 85-96, 2005.

K.C. Harvey, J.W. Hosch, N.B. Gallagher and B.M. Wise, “System and method for determining endpoint in etch processes using partial least squares discriminant analysis in the time domain of optical emission spectra,” US Patent No. 6,830,939; Dec. 14, 2004.

N.B. Gallagher, J.M. Shaver, E.B. Martin, J. Morris, B.M. Wise, and W. Windig, “Curve resolution for images with applications to TOF-SIMS and Raman,” Chemo. and Intell. Lab. Sys.77(1), 105-117, 2003.

N.B. Gallagher, J.M. Shaver, E.B. Martin, J. Morris, B.M. Wise and W. Windig, “Curve Resolution for Images with Applications to TOF-SIMS and Raman,” Chemo. and Intell. Lab. Sys., Vol. 77, No. 1, pps 105-117, 2003.

B.M. Wise, N.B. Gallagher and J.W. Grate, “Analysis of Combined Mass and Volume Transducing Sensor Arrays,” Journal of Chemometrics17(8-9), pps. 463-469, August-September, 2003.

N.B. Gallagher, B.M. Wise and D.M. Sheen, “Error Analysis for Estimation of Trace Vapor Concentration-Pathlength in Stack Plumes,” Applied Spectroscopy57(6), pps 614-621, June 2003.

H. Martens, M. Høy, B.M. Wise, R. Bro and P.B. Brockhoff, “Pre-whitening of data by covariance-weighted pre-processing,” Journal of Chemometrics17(3), pps 153-165, March 2003.

J.W. Grate, B.M. Wise and N.B. Gallagher, “Classical Least Squares Transformations of Sensor Array Pattern Vectors into Vapor Descriptors. Simulation of Arrays of Polymer-coated Surface Acoustic Wave Sensors with Mass-Plus-Volume Transduction Mechanisms,” Anal. Chim. Acta490(1), pps 169-184, 2003.

B.E. Goodlin, D.S. Boning, H.H. Sawin and B.M. Wise, “Simultaneous Fault Detection and Classification for Semiconductor Manufacturing Tools,” J. Electrochemical Society150(12), pps G778-G784, 2003.

N.B. Gallagher, B. M. Wise, and D.M. Sheen, “Estimation of Trace Vapor Concentration-Pathlength in Plumes for Remote Sensing Applications from Hyperspectral Images,” Anal. Chim. Acta490(1), pps 139-152, 2003.

N.B. Gallagher, D.M. Sheen, J.M. Shaver, B.M. Wise and J.F. Schultz, “Estimation of Trace Vapor Concentration-Pathlength in Plumes for Remote Sensing Applications from Hyperspectral Images,” SPIE Proceedings, Vol. 5093, pps 184-194, 2003.

J.W. Grate and B.M. Wise, “Methods for Characterizing, Classifying, and Identifying Unkowns in Samples,” US Patent 6,408,250, June 18, 2002.

B.M. Wise, N.B. Gallagher, R. Bro and J.M. Shaver, PLS_Toolbox for use with MATLAB,Version 3.0, Software, Eigenvector Research, Inc., November, 2002.

B.M. Wise, N.B. Gallagher and E.B. Martin, “Application of PARAFAC2 to Fault Detection and Diagnosis in Semiconductor Etch,” Journal of Chemometrics15(4), pps 285-298, 2001.

J.W. Grate, S.J. Patrash, S.N. Kaganove, M.H. Abraham, B.M. Wise and N.B. Gallagher, “Inverse Least Squares Modeling of Vapor Descriptors using Polymer-coated Surface Acoustic Wave Sensor Array Responses,” Analytical Chemistry73(21), pps 5247-5259, 2001.

D.M. Sheen, N.B. Gallagher, P.G. Heasler, J.F. Schultz, B.M. Wise, S.W. Sharpe and K.K. Anderson, “Infrared Chemical Detection Systems Modeling and Advanced Chemometric Analysis,” Pacific Northwest National Laboratory, PNNL-13737, December, 2001.

J.W. Grate and B.M. Wise, “A Method for Chemometric Classification of Unknown Vapors from the Responses of an Array of Volume-Transducing Sensors,” Analytical Chemistry73(10), pps 2239-2244, 2001.

S. de Jong, B. M. Wise and N. L. Ricker, “Canonical Partial Least Squares and Continuum Power Regression,” Journal of Chemometrics15(2), pps 85-100, 2001. Winner of the Unilever R&D Vlaardingen (URDV) Author Award for 2002.

B.M. Wise, “Cootie, Candyland or Chutes and Ladders: Solving a Parent’s Dilemma with Monte Carlo Simulation,” Game & Puzzle Collectors Quarterly, 1(3), pps 19-21, Sept., 2000.

J.W. Grate and B.M. Wise, “Chemical Information from Polymer-coated Acoustic Wave Sensor Arrays,” SPIE Conference on Chemical Microsensors and Applications II, SPIE Vol. 3857, pps 170-173, 1999.

J.W. Grate, B.M. Wise and M.J. Abraham, “Method for Unknown Vapor Characterization and Classification Using Multivariate Sorption Detector: Initial Derivation and Modeling Based on Polymer-coated Acoustic Wave Sensor Arrays and Linear Solvation Energy Relationships,” Analytical Chemistry71(20), pps 4544-4553, 1999.

J.W. Grate, S.J. Patrash, S.N. Kaganove and B.M. Wise, “Hydrogen Bond Acidic Polymers for Surface Acoustic Wave Vapor Sensors and Arrays,” Analytical Chemistry71(5), pps 1033-1040, 1999.

B.M. Wise, N.B. Gallagher, S.W. Butler, D. White and G.G. Barna, “A Comparison of Principal Components Analysis, Multi-way Principal Components Analysis, Tri-linear Decomposition and Parallel Factor Analysis for Fault Detection in a Semiconductor Etch Process,” Journal of Chemometrics13(3-4), pps 379-396, 1999.

B.M. Wise and N.B. Gallagher, “An Introduction to Linear Algebra,” Critical Reviews in Analytical Chemistry28(1), pps 1-19, 1998.

B.M. Wise and N.B. Gallagher, “Multi-way Analysis in Process Monitoring and Modeling,” AIChE Symposium Series, No. 316, vol.93, pps 271-274, 1997.

B.M. Wise, N.B. Gallagher, S.W. Butler, D. White and G.G. Barna, “Development and Benchmarking of Multivariate Statistical Process Control Tools for a Semiconductor Etch Process: Impact of Measurement Selection and Data Treatment on Sensitivity,” IFAC SAFEPROCESS’97, pps 35-42, Kingston Upon Hull, U.K., August 1997.

N.B. Gallagher, B.M. Wise, S.W. Butler, D. White and G.G. Barna, “Development and Benchmarking of Multivariate Statistical Process Control Tools for a Semiconductor Etch Process: Improving Robustness Through Model Updating,” IFAC ADCHEM’97, pps 78-83, Banff, Canada, June 1997.

D. White, G.G. Barna, S.W. Butler, B. Wise and N. Gallagher, “Methodology for Robust and Sensitive Fault Detection,” Electrochemical Society Meeting, Montreal, Vol. 97-9, pps 55-79, May, 1997.

B. M. Wise and N. B. Gallagher, “The Process Chemometrics Approach to Chemical Process Fault Detection and Supervision,” Journal of Process Control6(6), pps 329-348, 1996.

N.B. Gallagher, B.M. Wise and C.W. Stewart, “Application of Multi-way Principal Components Analysis to Nuclear Waste Storage Tank Monitoring,” Computers in Chem. Engng., 20(Suppl. A), pps s739-44, 1996.

B.M. Wise, B.R. Holt, N.B. Gallagher and S. Lee, “A Comparison of Neural Networks, Non-Linear Biased Regression and a Genetic Algorithm for Dynamic Model Identification,” Chemo. and Intell. Lab. Sys.30(1), pps. 81-89, 1995.

B.M. Wise and D. Haesloop, “A Non-Linear Dynamic Model Identification Challenge Problem,” Chemo. and Intell. Lab. Sys.30(1), pps 91-96, 1995.

B.M. Wise and B.R. Kowalski, “Process Chemometrics” in Process Analytical Chemistry, F. McLennan and B.R. Kowalski editors, Chapman & Hall, 1995.

B.M. Wise and F.R. Guenther, “Gas Sensors in Outdoor Environmental Monitoring and Site Remediation,” Proceedings of the NIST Workshop on Gas Sensors: Strategies for Future Technologies, NIST Special Publication 865, pps. 103-107, 1994.

B.M. Wise and N.L. Ricker, “Identification of Finite Impulse Response Models with Continuum Regression,” Journal of Chemometrics7(1), pps. 1-14, 1993.

B.M. Wise, “Using the PLS_Toolbox in PAC Applications,” Process Control and Quality, Vol. 5, 73-85, 1993.

B.M. Wise and B.R. Kowalski, “Process Chemometrics: The Case for Chemometrics in Chemical Engineering,” AIChE Computing and Systems Techology Division Communications16(2), pps. 5-11, 1993.

B.M. Wise and N.L. Ricker, “Identification of Finite Impulse Response Models by Principal Components Regression: Frequency-Response Properties,” Process Control and Quality, Vol. 4, pps. 77-86, 1992.

B.M. Wise and J. Janata, “Environmental Analysis (Chemical Sensor Applications),” in Encyclopedia of Energy Technology and the Environment, John Wiley and Sons, New York, 1995.

B. M. Wise, N. L. Ricker, D. F. Veltkamp and B. R. Kowalski, “A theoretical basis for the use of principal component models for monitoring multivariate processes,” Process Control and Quality, Vol. 1, pps. 41-51, 1990.

J. A. Bamberger, B. M. Wise and W. C. Miller, “Retrieval Technology Development for Hanford Double-Shell Tanks,” Spectrum ’92, Boise, ID, 1992.

B. M. Wise, “Adapting Multivariate Analysis for Monitoring and Modeling of Dynamic Systems,” Ph.D. Dissertation, University of Washington, Seattle, 1991.

B. M. Wise and N. L. Ricker, “Recent Advances in Multivariate Statistical Process Control: Improving Robustness and Sensitivity,” IFAC Symposium on Advanced Control of Chemical Processes, pps. 125-130, Toulouse, France, October 1991.

B. M. Wise and N. L. Ricker, “Feedback Strategies in Multiple Sensor Systems,” AIChE Symposium Series on Process Sensing, No. 267 Vol. 85, pps 19-23, 1989.

B. M. Wise, D. J. Veltkamp, N. L. Ricker, B. R. Kowalski, S. M. Barnes and V. Arakali, “Application of Multivariate Statistical Process Control (MSPC) to the West Valley Slurry-Fed Ceramic Melter Process,” Waste Management ’91 Proceedings, Vol. 2, pps 169-176, Tucson AZ 1991.

B. M. Wise and N. L. Ricker, “The Effect of Biased Regression on the Identification of FIR and ARX Models,” AIChE 1990 Annual Meeting, Nov. 1990.

B. M. Wise, N. L. Ricker and D. J. Veltkamp, “Upset and Sensor Failure Detection in Multivariate Processes,” AIChE 1989 Annual Meeting, Nov. 1989.

B. M. Wise, D. J. Veltkamp, B. Davis, N. L. Ricker and B. R. Kowalski, “Principal Components Analysis for Monitoring the West Valley Liquid Fed Ceramic Melter,” Waste Management ’88 Proceedings, pps. 811-818, Tucson AZ 1988.

B. M. Wise, “A Broad Interpretation of Chemometrics,” North American Chapter of the International Chemometrics Society Newsletter, No. 2, August, 1991.

B. M. Wise and A. H. McMakin, “A Statistical Technique for Analyzing Data from Liquid-Fed Ceramic Melters,” PNL-SA-15267, Pacific Northwest Laboratory, Richland, WA 1987.

B. M. Wise, “Development of a Piezoelectric Sensor to Monitor Fluid Properties and Flow Rates,” Master’s Thesis, University of Washington, Seattle, 1987.

R. A. Brouns, J. M. Perez, Jr., and B. M. Wise, “Selection of a Glass/Feed Composition for the West Valley Demonstration Project Slurry-Fed Melter,” American Nuclear Society Meeting, Spectrum ’86, Niagra Falls, NY, 1986.

S. M. Barnes, J. H. Westsik, Jr. and B. M. Wise, “Instrumentation Concepts for Nuclear Waste Glass Melters,” Waste Management ’85 Proceedings, Tucson 1985.

D. E. Carl, L. E. Rykken, J. R. Stimmel, and J.H. Marlow (WVNS), L. A. Bray and B. M. Wise (PNL), “Zeolite Variability in the WVDP HLW Glass Feed Streams,” Advances in Ceramics, Vol 20: Nuclear Waste Management II, 1985.

L. A. Bray, L. K. Holton, T. R. Myers, G. M. Richardson and B. M. Wise, “Experimental Data Developed to Support the Selection of a Treatment Process for West Valley Alkaline Supernatant,” PNL-4969, Pacific Northwest Laboratory, Richland Washington, 1984.

L. A. Bray, L. K. Holton Jr. and B. M. Wise (PNL), J. M. Pope and D. E. Carl (WVNS), “Selection of a Reference Process for Treatment of the West Valley Alkaline Waste,” American Nuclear Society International Topical Meeting Proceedings, Jackson Hole, WY August 1984.

The View From Eigenvector Notable Blog Posts:

Domain Knowledge and the New “Turn Your Data Into Gold” Rush, January 2020.

Classical Least Squares (CLS) with Nonlinear Spectra, October 2014.

Missing Data (part three), November 2011.

Missing Data (part two), November 2011.

Missing Data (part one), November 2011.

Switch from MLR to PLS?, April 2011.

Speed of PLS Algorithms, November 2010.

One Last Time on Accuracy of PLS Algorithms, September 2010.

Re-orthogonalization of PLS Algorithms, August 2010.

Accuracy of PLS Algorithms, August 2010.

Clustering in Images, August 2010.

Pseudoinverses, Rank and Significance, June 2010.

Continuum Regression illustrates differences between PCR, PLS and MLR, September 2009.

Different kinds of PLS weights, loadings, and what to look at?, September 2009.

What Works and What Doesn’t, June 2009.

NIPALS versus Lanczos Bidiagonalization, June 2008.

A Recipe for Failure, June 2007.

Selected Presentations and Manuscripts:

B.M. Wise, M.A. Palacios and D. O’Sullivan, “A New Data Compression Method for Classification Analysis,” SCIX Conference, Palm Springs, CA, October 2019.

B.M. Wise, A History of Multi-way Methods in Chemistry and Chemical Engineering, AI and Tensor Factorizations for Physical, Chemical and Biological Systems, Santa Fe, NM, September 2019.

B.M. Wise, D. O’Sullivan and M.A. Palacios, A Comparison of ANNs, SVMs & XGBoost on some Challenging Classification Problems,” APACT, Chester, UK, April, 2019.

B.M. Wise, Data Preprocessing for Quantitative and Qualitative Models Based on NIR Spectroscopy,” Rapid Estimation of Fish Age Using Fourier Transform-near Infrared Spectroscopy (FT-NIRS), NOAA, Seattle, April, 2019.

B.M. Wise, Common Chemometric Mistakes and How to Avoid Them,” PittCon, Philadelphia, PA, March, 2019.

B.M. Wise and J.M. Shaver, “Detection of Cervical Cancer from Evoked Tissue Fluorescence Images Using 2- and 3-way Methods,” SPIE Photonics West, San Francisco, February 2019.

B.M. Wise, “ASCA and MLSCA for Process and Instrument Characterization,” CPAC Summer Institute, Seattle, WA, August, 2018.

B.M. Wise, “Visualization of Two-way, Three-way and Higher Order Data Sets,” Arctic Analysis, Iceland, 2018.

B.M. Wise and R. Scott Koch, “Integrating Instrument Standardization Methods into Data Preprocessing Schemes,” EAS 2017, Princeton, NJ, November 2017.

B.M. Wise, “Introduction to Principal Components Analysis & Related Methods on Multivariate/Hyperspectral Images,: NALM Harvard Workshop, Cambridge, MA, November 2017.

B.M. Wise, “Alternative Model Forms for Multi-set, Multi-level and Multi-block Data,” IFPAC 2016, Baltimore, MD, February 2016.

B.M. Wise, “Using Clutter to Improve Models,” Chimiometrie 2016, Namur, Belgium, January 2016.

B.M. Wise and W. Windig, “Enhancing Chemical Contrast: Latest Trends in Hyperspectral Image Analysis,” AVS 62nd Annual Symposium, San Jose, CA, October, 2015.

B.M. Wise and R.T. Roginski, “Model Maintenance: when, how and how to avoid it,” Chemometrics in Analytical Chemistry CAC-2015, Changsha, China, June, 2015.

B.M. Wise and R.T. Roginski, “Model Maintenance—The Unrecognized Cost in PAT and QbD,” EuroPACT, Barcelona, Spain, 2014.

B.M. Wise, “Stealing from Psychometrics: Batch Statistical Process Control (BSPC) ,” Pieter Kroonenberg Farewell Symposium, Leiden University, Belgium, November, 2014

B.M. Wise and J.M. Shaver, “Knowing when to Quit: Why do we waste so much time trying to get models out of bad data?,” Meeting of the Danish Chemometrics Society, Nyborg, Denmark, November, 2014.

B.M. Wise, “Impact of Chemometrics: Industrial Perspective and The View from Eigenvector,” CPAC Symposium Remembering Bruce Kowalski, University of Washington, Seattle, WA, November, 2013.

B.M. Wise and J.M. Shaver, “Are O-PLS Models Really More Interpretable?,” SCIX Conference, Milwaukee, WI, September, 2013.

B.M. Wise, J.M. Shaver and N.B. Gallagher, “Orthogonalization Approaches for Data Preprocessing with Pharmaceutical, Petrochemical and Remote Sensing Applications,”APACT 13, Chester, UK, April, 2013.

B.M. Wise, J.M. Shaver and N.B. Gallagher, “Getting_to_Multiway,” Three-way Methods in Chemistry and Psychology, TRICAP 2012, Brugge, Belgium, June, 2012.

B.M. Wise and N.B. Gallagher, “Multivariate Modeling of Batch Processes Using Summary Variables,” FACSS Conference, Reno, NV, October, 2011.

B.M. Wise, J.M. Shaver, N.B. Gallagher and R. Bro, “Orthogonalization Filter Preprocessing in NIR Spectroscopy,” SSC-12, Bilund, Denmark, June 2011.

P. Gujral, B.M. Wise, M. Amrhein and D. Bonvin, “On the bias-variance trade-off in principal component regression with unlabeled data,” SSC-11, Trondheim, Norway, June 2009.

P. Gujral, M. Amrhein, B.M. Wise, E. Guzman, D. Chivala and D. Bonvin, “Correction of systematic disturbances in latent-variable calibration models,” SSC-11, Trondheim, Norway, June 2009.

B.M. Wise, “Re-fitting PCA, MPCA and PARAFAC Models to Incomplete Data Records,” FACSS, Memphis, TN, October, 2007.

B.M. Wise, “How to Swallow a Mouthful of Data and Avoid Indigestion,” Sematech AEC/APC Conference, Indian Wells, CA, September, 2007.

B.M. Wise, “Multivariate Analysis for TOF-SIMS,” 20th SIMS Workshop, Key Largo, FL, May, 2007.

B.M. Wise, N.B. Gallagher, R.M. Ozanich and Jay W. Grate, “A Holistic Approach to Sensor and Analytical Method Development,” FACSS, Lake Buena Vista, FL, September, 2006.

B.M. Wise, “A Successful Marriage between Chemometrics and Industry? I could tell you but then I’d have to kill you,” FACSS, Lake Buena Vista, FL, September, 2006.

B.M. Wise, “Partial Re-fitting of PCA and PARAFAC Models to Incomplete Data Records, Three-way Method in Chemistry and Psycholgy-TRICAP, Chania, Crete, Greece, June 2006.

B.M. Wise, N.B. Gallagher and R.M. Ozanich, “Model-based Variable Selection,” 10th International Conference on Chemometrics in Analytical Chemistry, Aguas de Lindoia, Brazil, September 2006.

B. Marshik, B.M. Wise, H. Martens and H. Tan, “Improved NIR-based Detection of Vulnerable Plaques using GLS Pre-processing,” submitted to Applied Spectroscopy, May 2004.

B.M. Wise, H. Martens and M. Høy, “Calibration Transfer by Generalized Least Squares Preprocessing,” submitted to Applied Spectroscopy, February, 2003.

B.M. Wise, “Tales from the Edge of Chemical Engineering,” EAS Chemometrics Award Lecture, Eastern Analytical Symposium, Atlantic City, NJ, October 1, 2001.

B.M. Wise, H. Martens, M. Høy, R. Bro and P. B. Brockhoff, “Calibration Transfer by Generalized Least Squares,” Seventh Scandinavian Symposium on Chemometrics (SSC7), Copenhagen, Denmark, August 2001.

B.M. Wise, “Analysis and Display of Historical Stehekin River Flow Data with Robust PCA Methods,” Seventh Scandinavian Symposium on Chemometrics (SSC7), Copenhagen, Denmark, August 2001.

P.R. Moreno, S.E. Ryan, D.W. Hopkins, K-R. Purushothaman, B.M. Wise, R. Kryscio, H. Mark, R. Kramer, W.E. Charash, W.N. O’Connor, and J.E. Muller, “Identification of Lipid-Rich Plaques in Human Coronary Artery Autopsy Specimens by Near-Infrared Spectroscopy,” American College of Cardiology National Meeting, Orlando, FL, March 20, 2001.

P.R. Moreno, S.E. Ryan, D.W. Hopkins, K-R. Purushotaman, B.M. Wise, W.E. Charash, W.N. O’Connor, and J.E. Muller, “Detection of Lipid-Rich Plaques With Near Infrared Spectroscopy In-Vivo,” American College of Cardiology National Meeting, Orlando, FL, March 20, 2001.

B.M. Wise, “What is Chemometrics,” 13th Sanibel Conference on Mass Spectrometry, January 2001.

B.M. Wise and P. Geladi, “Analysis of a Series of Images with PCA and PARAFAC,” TRICAP 2000: Three-way Methods in Chemistry and Psychology, Fåborg, Denmark, July 2000.

B.M. Wise and P. Geladi, “A Brief Introduction to Multivariate Image Analysis,” North American/International Chemometrics Sociey Newsletter, November, 2000.

B.M. Wise, N.B. Gallagher, J.D. Londono and R. Harlow, “Three-way Analysis of Small Angle X-Ray Scattering: Coordinate Transformations and Morphing,” TRICAP 2000: Three-way Methods in Chemistry and Psychology, Fåborg, Denmark, July 2000.

B.M. Wise, “Introduction to Standardization and Calibration Transfer,” Shedding New Light on Disease: Optical Diaganostics for a New Millenium, Winnipeg, CA, June 2000.

B.M. Wise, N.B. Gallagher and J.W. Grate, “Using Virtual Instruments for Optimizing Configuration and Data Treatment in Analytical Systems,” Eastern Analytical Symposium, Somerset, NJ, November, 1999.

B.M. Wise, N.B. Gallagher and J.W. Grate, “Rank Imposed Limitations and Opportunities in Acoustic Wave Sensors,” Federation of Analytical Chemistry and Spectroscopy Societies, Vancouver, BC, October 1999.

B.M. Wise, “What Chemometricians and Chemical Engineers Refuse to Learn from Each Other,” 6th Scandinavian Symposium on Chemometrics (SSC6), Porsgrunn, Norway, August 1999.

B.M. Wise, “Multi-way Methods in Multivariate Statistical Process Control (MSPC),” Center for Process Analytical Chemistry Summer Institute (CPAC-SI), Seattle, WA, July 1999.

B.M. Wise, “The Promise of Multi-way Methods in Environmental Applications,” Central Europe-USA Workshop on Environmental Chemistry, Prague, Czech Republic, June 1999.

B.M. Wise, “New Frontiers in Chemometrics: An Introduction to Curve Resolution and Multi-way Methods,” Society of Applied Spectroscopy 1999 Chicago Workshop, Naperville, IL, February 1999.

B.M. Wise and N.B. Gallagher, “Variable Selection for PLS Calibration Models by Genetic Algorithm,” American Statistical Association Annual Meeting, Dallas, TX, August 1998.

B.M. Wise, “Virtual Sensor Models for Optimizing Sensor Configuration and Data Treatment,” Gordon Research Conference on Sensors and Interfacial Materials, Henniker, NH, July 1998.

B.M. Wise and N.B. Gallagher, “Double Window Piece-wise Direct Standardization,” Federation of Analytical Chemistry and Spectroscopy Societies, Austin, Texas, October 1998.

S.W. Butler and B.M. Wise, “Unsolved Problems and Partial Solutions in Multivariate Statistical Process Control,” Gordon Research Conference on Statistics in Chemistry and Chemical Engineering, Oxford, England, August 1996.

B.M. Wise, N.B. Gallagher, P.A. Eschbach, S.W. Sharpe and J.W. Griffin, “Optimization of Prediction Error Using Genetic Algorithms and Continuum Regression: Determination of the Reactivity of Automobile Emissions from FTIR Spectra,” Fourth Scandanavian Symposium on Chemometrics (SSC4), Lund, Sweden, June 1995.

B. M. Wise and B. R. Kowalski, “Multivariate Calibration Made Easy: Is it Possible?” Federation of Analytical Chemistry and Spectroscopy Socities, Detroit, MI, October 1993.

B. M. Wise and B. R. Holt, “A Comparison of Neural Networks, Non-linear Biased Regression and a Genetic Algorithm” Federation of Analytical Chemistry and Spectroscopy Socities, Detroit, MI, October 1993.

R. H. Taylor, J. W. Grate and B. M. Wise, “Using Flow Injection Techniques to Minimize Laboratory Waste,” Defense Programs: The Greening of the Complex, Pleasanton, CA, October 1993.

B. M. Wise, “Multivariate Analysis for PAC with the PLS_Toolbox,” MATLAB User’s Conference, Cambridge, MA, October 1993.

B. M. Wise, “Second Order Devices: The Coming Revolution in Sensing,” NIST, Gaithersburg, MD, September, 1993.

B. M. Wise and S. D. Colson, “Development of a Laser Ablation/Mass Spectrometry System for Waste Tank Analysis,” CPAC Semi-Annual Sponsor Meeting, Seattle, WA, November 1993.

B. M. Wise, “Monitoring the Health of Multi-Channel Analytical Instruments with Multivariate Statistical Process Control (MSPC),” Chemometrics in Analytical Chemistry ’92, Montreal, 1992.

B. M. Wise, S. Lee, B. R. Holt, N. L. Ricker and D. Haesloop, “A Comparison of Neural Networks and Nonlinear Regression Techniques for Dynamic Model Identification,” 1992 AIChE Annual Meeting, Miami Beach, FL, 1992.

B. M. Wise and D. J. Veltkamp, “Biased Regression for Identification of Dynamic and Statistical Process Control Models,” Federation of Analytical Chemistry and Spectroscopy Societies XIX, September 1992.

B. M. Wise, “The Multivariate Statistical Process Control Approach to Process Diagnostics,” ACS Symposium on Chemical Diagnostics for Chemical & Materials Synthesis Processes, San Francisco, April 1992.

B. M. Wise, “The Effect of Biased Regression on Dynamic Model Identification,” ANATECH ’92, Lake Lanier Islands, GA, 1992.

B. M. Wise, “Biased Regression for Dynamic Model Identification,” presented to the University of Texas, Department of Chemical Engineering, May, 1992. 

B. M. Wise, “Using the PLS_Toolbox for Process Modeling and Fault Detection,” American Control Conference, June 1993.