Eigenvector University Europe is in Rome, ITALY October 14-17, 2024 Complete Info Here!

Calibration Model Maintenance

February 25, 2021

The recorded version of this course is now available in our EigenU Recorded Courses area.

Eigenvector Research, Inc. is pleased to bring you Calibration Model Maintenance, an online instructor-led live short course. Complete information about the course can be found by following the links below.

Course Description

Model maintenance can be defined as the on-going servicing of (primarily) multivariate calibration and fault detection models in order to preserve their predictive abilities. It is required because of changes to either the sample matrices or the instrument response. The goal of model maintenance is to sustain or improve models over time and changing conditions with the least amount of cost and effort. This course presents a roadmap for determining when model maintenance is required, the probable source of the response variations, and the appropriate approaches for achieving it. Hands-on exercises will be done using PLS_Toolbox/Solo.


Linear Algebra for Chemometricians, Chemometrics I — PCA, and Chemometrics II – Regression and PLS or equivalent experience.

Course Outline

  1. Introduction to Model Maintenance
    1. Goals
    2. Causes of data/model mismatch
  2. Identifying the need for action
    1. External validation samples
    2. Model prediction diagnostics Q and T^2
    3. Setting action limits
    4. Determining the source of the problem
  3. Model updating methods
    1. Slope and bias adjustments
    2. Adding to the calibration set
    3. Automatic model updating
  4. Instrument standardization methods
    1. Direct and Piecewise Direct standardization
    2. Spectral Subspace Transformation
    3. Filtering approaches: GLS and OSC
  5. Avoiding model updating
    1. Preprocessing methods that tend to make model more brittle
    2. Using the model robustness tests
  6. Conclusions

Course Fee

Prices include instruction, course materials (provided in advance in .pdf format), a certificate of completion and access to the recorded class sessions. Prices shown are shown below. Payment must be received by 5pm PST, Monday, February 22, 2021.

Calibration Model Maintenance

Note: Payment must be received by 5pm PST, Monday, February 22, 2021. Credit card orders are strongly encouraged. Acceptable forms of payment include MasterCard, VISA, American Express, and checks drawn on a US bank. Wire transfers can also be arranged.

Academic discount: University students and faculty are eligible for the academic rate. Verification of University affiliation is required by providing valid university mailing and e-mail address. Note that we define academic as “degree granting institution.”

How to Register, Deadlines and Cancellations

To register, login to your Eigenvector account, or create an account, then select the class you would like to attend under the “Purchase” tab. You can pay directly with your MasterCard, VISA or American Express using our secure credit card processing. You may ask to be invoiced, however, Payments must be received by 5pm PST, Monday, February 22, 2021.

Complete refunds will be made for cancellations prior to Friday, February 19, 2021. No refunds will be made for cancellations after that date, however, substitutions are gladly accepted.


Calibration Model Maintenance will be taught in a single session of 3.5 hours on Thursday, February 25. The schedule will be as follows.

Daily Schedule, Pacific Standard Time (PDT)
06:45 – 07:00 WebEx available for login*
07:00 – 08:00 Instruction
08:00 – 08:10 Coffee Break
08:10 – 09:10 Instruction
09:10 – 09:20 Coffee Break
09:20 – 10:20 Instruction
10:20 – 10:30 Wrap-up and questions

* 7:00 am PST is 10:00am in New York, 15:00 in London and 16:00 in Paris.

Can’t make it at this time? The sessions will be recorded and made available to course participants for their use for one year after the event.