Willem Windig , Ph.D.

Chief Eigenspectroscopist, 
Eigenvector Research, Inc.

phone: (585) 663-1139 
e-mail: windig@eigenvector.com

Education:

A.S., Fine Arts, with distinction, 2000, Monroe Community College, Rochester, NY
Ph.D., Biology and Physics, 1982 University of Utrecht, The Netherlands 
M.S., Biology and Physics, with teacher certification, 1977 University of Amsterdam, The Netherlands 
B.S., Biology and Physics, 1973 University of Amsterdam, The Netherlands

Experience:

Research Associate, 1994-2002, Senior Scientist, 1988-1994, Eastman Kodak Company, Rochester, NY 
Senior Scientist I, 1987-1988 Geo Centers Inc., Ft. Washington, Maryland 
Senior Research Associate 1985-1987 Postdoctoral fellow 1982-1985 Biomaterials Profiling Center University of Utah, Salt Lake City, Utah

Research Interests:

Development of multivariate data analysis techniques and their application to solve actual problems. Development of user-friendly software to apply these techniques.

Honors:

Member of editorial advisory board of ‘Chemometrics and Intelligent Laboratory Systems’.

Patents:

R. Schweitzer, P.J. Treado, W. Windig, “Method for Identifying Components of a Mixture via Spectral Analysis,” US Patent 7,072,770, July 4, 2006.

W. Windig, “Method for Comparison of Similar Samples in Liquid Chromatography/Mass Spectrometry, US Patent 6,329,652 B1,” Dec. 11, 2001.

W. Windig and B. Antalek, “Image Analysis Using the Direct Exponential Curve Resolution Algorithm, U.S. Patent 5,841,891,” Nov. 24, 1998.

W. Windig and A.W. Payne, “Noise and Background Reduction Method for Component Detection in Chromatography/Spectrometry,” US Patent 5.672,896, Sep. 30, 1997.

W. Windig, “Apparatus for Interactive Self-Modeling Mixture Analysis,” US Patent 5,481,476, Jan. 2, 1996.

Publications (refereed journals):

W. Windig, J.M. Shaver and R. Bro, Loopy MSC, a Simple Way to Improve Multiplicative Scatter Correction, Applied Spectroscopy, October 2008, in press.

W. Windig, B.Antalek, J.L. Lippert, Y. Batonneau and C. Bremard, Combined Use of Conventional and Second-derivative Data in the SIMPLISMA Self-modeling Mixture Analysis Approach, Anal. Chem., in press.

N.B. Gallagher, J.M. Shaver, W. Windig, T.A. Blake, and P.L. Gassman, “Multivariate Curve Resolution Applied to Infrared Reflectance Measurements of Soil Contaminated with Organic Analyte” Appl. Spectrosc., 60(7), 713-722 (2006).

W. Windig, N.B. Gallagher, J.M. Shaver and B.M. Wise, ” New Approach for Interactive Self-Modeling Mixture Analysis,” Chemometr. Intell. Lab., 77(1-2), 85-96 (2005).

N.B. Gallagher, J.M Shaver, E.B. Martin, J. Morris, B.M. Wise and W.Windig, Curve resolution for images with applications to TOF-SIMS and Raman, Chemometrics and Intelligent Laboratory Systems 77, 2003, 105-117.

B. Antalek, J.M Hewitt, W. Windig. P.D. Yacobucci, T. Mourey and Kim Le, The use of PGSE NMR and DECRA for determining polymer composition, Mag. Reson. in Chem., 40, 2002, S60-S71.

W. Windig, W.F. Smith, W.F. Nichols, Fast Interpretation of Complex LC/MS Data Using Chemometrics, Anal. Chim. Act 446, 2001, 467-476.

W. Windig, B. Antalek, M.J. Robbins, N. Zumbulyadis and C.E. Heckler, Applications of the Direct Exponential Curve Resolution Algorithm (DECRA) to Solid State Nuclear Magnetic Resonance and Mid-infrared Spectra, J. Chemometrics, 14, 2000, 213-227.

N. Zumbulyadis, B. Antalek, W. Windig, R.P. Scaringe, A.M. Lanzafame, T. Blanton and M. Helber, Elucidation of Polymorph Mixtures Using Solid-State 13C CP/MAS NMR Spectroscopy and Direct Exponential Curve Resolution Algorithm, JACS, 121, 1999, 11554-11557.

W. Windig, B. Antalek, L.J. Sorriero, S. Bijlsma, D.J. Louwerse and A.K. Smilde, Applications and New Developments of the Direct Exponential Curve Resolution Algorithm (DECRA). Examples of Spectra and Magnetic Resonance Images, J. Chemom., 13, 1999, 95-110.

S. Bijlsma, D.J. Louwerse, W. Windig and A.K. Smilde, Rapid Estimation of Rate Constants Using On-line SW-NIR and Trilinear Models, Anal. Chim. Act., 376, 1998, 339-355.

W. Windig and B. Antalek, Resolving Nuclear Magnetic Resonance Data of Mixtures by 3-way analysis. Examples of Chemical Solutions and the Human Brain, Chemom. and Intell. Lab. Syst., 46, 1999, 207.

W. Windig, J.P. Hornak and B. Antalek, Multivariate Analysis of Magnetic Resonance Images with the Direct Exponential Curve Resolution Algorithm (DECRA), Part 1: Algorithm and Model Study, JMR, 132, 1998, 298-306.

B. Antalek, J.P. Hornak and W. Windig, Multivariate Analysis of Magnetic Resonance Images with the Direct Exponential Curve Resolution Algorithm (DECRA), Part 2: Application to Human Brain Images, JMR, 132, 1998, 307-135.

W. Windig and B. Antalek, Direct Exponential Curve Resolution (DECRA): A Novel Application of the Generalized Rank Annihilation Method for a Single Spectral Mixture Data Set with Exponentially Decaying Profiles, Chemometrics and Intelligent Laboratory Systems, 37, 1997, 241-254.

W. Windig, Spectral Data Files for Self-Modeling Curve Resolution with Examples Using the SIMPLISMA Approach, Chemometrics and Intelligent Laboratory Systems, 36, 1997, 3-16.

W. Windig, J.M. Phalp and A.W. Payne, A Noise and Background Reduction Method for Component Detection in Liquid Chromatography/Mass Spectrometry, Anal. Chem., 68, 1996, 3602-3603.

B. Antalek and W. Windig, Generalized Rank Annihilation Method Applied to a Single Multicomponent Pulsed Gradient Spin Echo NMR Data set, J. Am. Chem. Soc., 118, 1996, 10331-10332.

J.M. Phalp, A.W. Payne and W. Windig, The Resolution of Mixtures Using Data from Automated Probe Mass Spectrometry, Anal. Chim. Act., 318,1995, 43-53.

W. Windig, D.E. Margevich and W.P. McKenna, A Novel Tool for Two-Dimensional (2D) Correlation Spectroscopy, Chemometrics and Intelligent Laboratory Systems, 28, 1995, 108-128.

W. Windig, The Use of Second-Derivative Spectra for Pure-Variable Based Self-Modeling Mixture Analysis Techniques, Chemometrics and Intelligent Laboratory Systems, 23, 1994, 71-86.

J. Guilment, S. Markel and W. Windig, Infrared Chemical Micro-Imaging Assisted by Interactive Self-Modeling Multivariate Analysis, Appl. Spectr., 48, 1994, 320-326.

W. Windig and S. Markel, Simple-to-Use Interactive Self-Modeling Mixture Analysis of FTIR Microscopy Data, J. Mol. Struct., 292, (1993), 161-170.

W. Windig, Self-Modeling Mixture Analysis of Spectral Data with Continuous Concentration Profiles, Chemometrics and Intelligent Laboratory Systems, 16, 1992, 1-16.

W. Windig and D.A. Stephenson, Self-Modeling Mixture Analysis of Second-Derivative Near Infrared Spectral Data Using the SIMPLISMA Approach, Anal. Chem., 62, 1992, 2735-2742.

W. Windig, C.E. Heckler, F.A. Agblevor and R.J. Evans, Self-Modeling Mixture Analysis of Categorized Pyrolysis Mass Spectral Data with the SIMPLISMA Approach, Chemometrics and Intelligent Laboratory Systems, 14, 1992, 195-206.

W. Windig and J. Guilment, Interactive Self-Modeling Mixture Analysis, Anal. Chem., 63, 1991, 1425-1432.

A.P. Snyder, W. Windig and J.P. Toth, Interactive Self-Modeling Multivariate Analysis of Thermolysis Mass Spectra, Chemometrics and Intelligent Laboratory Systems, 11, 1991, 149-160.

W. Windig, J.L. Lippert, M.J. Robbins, K.R. Kresinske, J.P. Twist and A.P. Snyder, Interactive Self-Modeling Multivariate Analysis, Chemometrics and Intelligent Laboratory Systems, 9, 1990, 7-30.

W. Windig, Mixture Analysis of Spectral Methods by Multivariate Methods, Chemometrics and Intelligent Laboratory Systems, 9, 1990, 7-30.

M. Nip, J.W. de Leeuw, P.A. Schenck, W. Windig, H.L.C. Meuzelaar and J.C. Crelling, A Flash Pyrolysis Petrographic Study of Cutinite from the Indiana Paper Coal, Geochim. et Cosmochim. Acta, 53, 1989, 671-683.

W. Windig, S.A. Liebman, M.B. Wasserman and A.P. Snyder, Fast Self-Modeling Curve Resolution Method for Time Resolved Mass Spectral Data, Anal. Chem., 60, 1988, 1503-1509.

A.P. Snyder, J.H. Kremer, H.L.C. Meuzelaar and W. Windig, Curie-Point Pyrolysis Atmospheric Pressure Chemical Ionization Mass Spectrometry as a Probe on the Effect of Sodium Chloride on Biopolymers, J. Anal. Appl. Pyr., 13, 1988, 77-88.

A.P. Snyder, G.A. Eiceman and Willem Windig, Influence of Pyrolytic Techniques on Mass Spectra of Biopolymers with Chemical Ionization at Atmospheric Pressure, J. Anal. Appl. Pyrol, 13, 1988, 243-257.

E. Jakab, B.L. Hoesterey, W. Windig, G.R. Hill and H.L.C. Meuzelaar, Effects of Low Temperature Air Oxidation (Weathering) Reactions on the Pyrolysis Mass Spectra of U.S. Coals, Fuel, 67, 1988, 73-80.

W. Windig, E. Jakab, J.M. Richards and H.L.C. Meuzelaar, Self-Modeling Curve Resolution by Factor Analysis of a Continuous Series of Pyrolysis Mass Spectra, Anal. Chem., 59, 1987, 317-323.

G.S. Metcalf, W. Windig, G.R. Hill and H.L.C. Meuzelaar, Characterization of U.S. Lignites by Pyrolysis Mass Spectrometry and Multivariate Analysis, Coal Geology, 7, 1987, 245-268.

W. Windig, W.H. McClennen and H.L.C. Meuzelaar, Determination of Fractional Concentrations and Exact Component Spectra by Factor Analysis of Pyrolysis Mass Spectra of Mixtures, Chemometrics and Intelligent Laboratory Systems, 1, 1987, 151-165.

A.P. Snyder, J.H. Kremer, W. Windig, H.L.C. Meuzelaar and K. Taghizadeh, Curie-point Pyrolysis Atmospheric Pressure Chemical Ionization Mass Spectrometry: Preliminary Performance Data for Three Biopolymers, Anal. Chem., 59, 1987, 1945-1951.

H.L.C. Meuzelaar, B.L. Hoesterey, W. Windig and G.R. Hill, Prediction and Modeling of Coal Conversion Reactions by Pyrolysis Mass Spectrometry and Multivariate Statistical Analysis, Fuels Processing Technology, 15, 1987, 59-70.

T. Chakravarty, W. Windig, K. Taghizadeh, H.L.C. Meuzelaar and L.J. Shadle, Computer-Assisted Interpretation of Pyrolysis Mass Spectra of Two Oil Shales and their Corresponding Kerogens, Energy and Fuels, 2, 1986, 191-196.

H.L.C. Meuzelaar, W. Windig, S.M. Huff and J.M. Richards, Process Monitoring and Quality Assurance of Polymeric Materials by Computerized Pyrolysis Mass Spectrometry, Anal. Chim. Act., 190, 1986, 119-132.

W. Windig, T. Chakravarty, J.M. Richards and H.L.C. Meuzelaar, Multivariate Analysis of Time-Resolved Mass Spectral Data, Anal. Chim. Act., 191, 1986, 205-218.

W. Windig, W.H. McClennen, H. Stolk and H.L.C. Meuzelaar, Unsupervised Chemical Pattern Recognition in Complex Mass Spectra, Optical Engineering, 25, 1986, 117-122.

S.M. Huff, J.M. Matsen, W. Windig and H.L.C. Meuzelaar, Pyrolysis Mass Spectrometry of Bacteria from Infected Human Urine: I. Influence of Culturing and Antibiotics, Biomedical and Environmental Mass Spectrometry, 13, 1986, 277-286.

J.L. Savoca, R.P. Lattimer, J.M. Richards, W. Windig and H.L.C. Meuzelaar, Pyrolysis Mass Spectrometry Correlations of Crosslink Density in Natural Rubber Vulcanizates, J. Anal. Appl. Pyrol., 9, 1985, 19-28.

R.P. Lattimer, K.M. Schur, W. Windig and H.L.C. Meuzelaar, Quantitative Analysis of Rubber Triblends by Pyrolysis Mass Spectrometry, J. Anal. Appl. Pyrol., 8, 1985, 95-107.

H.L.C. Meuzelaar, W. Windig, A.M. Harper, S.M. Huff, W.H. McClennen and J.M. Richards, Pyrolysis Mass Spectrometry of Complex Organic Materials, Science, 226, 1984, 268-274.

A.C.M. Weyman, G.W. van Eijk, H.J. Roeijmans, W. Windig, J. Haverkamp and L.J. Turkensteen, Mass Spectrometric Techniques as Aids in the Diagnosis of Gangrene in Potatoes Caused by Phoma exigua var. foveata, (Forster) Boerema, Neth. J. Pl. Path., 90, 1984, 107-115.

G. Halma, D. van Dam, J. Haverkamp, W. Windig and H.L.C. Meuzelaar, Characterization of an Oligotrophic-Eutrophic Peat Sequence by Pyrolysis Mass Spectrometry and Conventional Analysis Methods, J. Anal. Appl. Pyrol., 7, 1984, 167-183.

W. Windig, H.L.C. Meuzelaar, F. Shafizadeh and R.G. Kelsey, Biochemical Analysis of Wood and Wood Products by Pyrolysis Mass Spectrometry and Multivariate Analysis, J. Anal. Appl. Pyrol., 6, 1984, 233-250.

W. Windig and H.L.C. Meuzelaar, Nonsupervised Numerical Extraction from Pyrolysis Mass Spectra of Complex Mixtures, Anal. Chem., 56, 1984, 2297-2303.

H.L.C. Meuzelaar, S.M. Huff, W. Windig and P. Kenemans, Pyrolyse Massaspektrometrie in Klinisch-Chemisch Perspectief, Tijdschrift NVKC, 1984, 47-52.

W. Windig, H.L.C. Meuzelaar and M. Jacobson, Embryos of Xenopis Leavis as a Model for Pyrolysis Mass Spectrometry Studies, J. Anal. Appl. Pyrol., 5, 1983, 349-362.

W. Windig, H.L.C. Meuzelaar, B.A. Haws, W.F. Campbell and K.H. Asay, Biochemical Differences in Pyrolysis Mass Spectra of Range Grasses with Different Resistance to Labops Hesperius (Uhler) Attack, J. Anal. Appl. Pyrol., 2, 1983, 183-198.

J.J. Boon, W. Windig, R.G. Wetzel and G.L. Godshalk, Analysis of Particulate Organic Matter from Myriophyllum by Pyrolysis Mass Spectrometry, Aquat. Bot. 15, 1983, 307-320.

W. Windig, J.Haverkamp and P.G. Kistemaker, Chemical Interpretation of Sets of Pyrolysis Mass Spectra by Discriminant Analysis and Graphical Rotation, Anal. Chem. 55, 1983, 81-88.

W. Windig, H.L.C. Meuzelaar and J. Haverkamp, Pyrolysis Mass Spectrometry of Virus-Infected Plants and Fungi, Phytopathology, Proc. C 86 (3), 1983, 437-444.

W. Windig and G.S. de Hoog, Pyrolysis Mass Spectrometry, I. Sporidiobolus, Stud. Mycol., 22, 1982, 60-64.

W. Windig and J. Haverkamp, Pyrolysis Mass Spectrometry, I. Rhodosporidium, Stud. Mycol., 22, 1982, 56-59.

W. Windig, P.G. Kistemaker and J.Haverkamp, Chemical Interpretation of Differences in Pyrolysis Mass Spectra of Simulated Mixtures of Biopolymers by Factor Analysis with Graphical Rotation, J. Anal. Appl. Pyrol., 3, 1981, 199-212.

D. van de Meent, J.W. de Leeuw, P.A. Schenck, W. Windig and J. Haverkamp, Quantitative Analysis of Biopolymers Mixtures by Pyrolysis Mass Spectrometry, J. Anal. Appl. Pyrol., 2, 1982, 133-142.

W. Windig, G.S. de Hoog and J. Haverkamp, Chemical Characterization of Yeasts and Yeast-like Fungi by Factor Analysis of their Pyrolysis Mass Spectra, J. Anal. Appl. Pyrol., 2, 1981, 213-220.

W. Windig, J. Haverkamp and A.L. van Wezel, Control on the Absence of DEAE-Polysaccharides in DEAE-Sephadex Purified Poliovirus Suspensions by Pyrolysis Mass Spectrometry, Develop. Biol. Standard. 47, 1980, 169-177.

W. Windig, P.G. Kistemaker, J. Haverkamp and H.L.C. Meuzelaar, Factor Analysis of the Influence of Changes in Experimental Conditions in Pyrolysis Mass Spectrometry, J. Anal. Appl. Pyrol., 2, 1980, 7-18.

J. Haverkamp, P.G. Kistemaker, A.J.H. Boerboom, W. Eshuis, G. Wieten and W. Windig, Toepassingen van Pyrolyse Massaspectrometrie in de Klinische Chemie, Mededelingen Ned. Ver. voor Klinische Chemie, 4, 1979, 188-202.

W. Windig, P.G. Kistemaker, J. Haverkamp and H.L.C. Meuzelaar, The Effects of Sample Preparation, Pyrolysis and Pyrolyzate Transfer Conditions on Pyrolysis Mass Spectra, J. Anal. Appl. Pyrol., 1, 1979, 39-52.

Publications (book chapters and full length proceedings):

W. Windig, S. Markel and P.M. Thompson, Self-modeling Image Analysis with SIMPLISMA, in H.F. Grahn and P. Geladi (eds.) , “Techniques and Applications of Hyperspectral Image Analysis”, John Wiley & Sons, Ltd, 2007, pp. 69-88

B. Antalek, W. Windig and J.P. Hornak, Multivariate Image Analysis of Magnetic Resonance Images: Component Resolution with the Direct Exponential Curve Resolution Algorithm (DECRA), in H.F. Grahn and P. Geladi (eds.) , “Techniques and Applications of Hyperspectral Image Analysis”, John Wiley & Sons, Ltd, 2007, pp. 261-288.

W. Windig, Mixture Analysis of Spectral Data by Multivariate Methods, in D.L. Massart, R.G. Brereton, R.E. Dessy, P.K. Hopke, C.H. Spiegelman, W. Wegscheider (eds.), “Chemometrics Tutorials”, Elsevier, 1990, pp. 293-305.

W. Windig, A Simple-to-use Method for Interactive Self-Modeling Mixture Analysis, in P.C. Jurs (ed). “Computer-Enhanced Analytical Spectroscopy”, Volume 3, Plenum Press, New York, 1992, pp. 67-102.

G.A. Eiceman, W. Windig and A.P. Snyder, Gas Chromatography of Microorganisms, in R.E. Clement (ed.), “Gas Chromatography: Biochemical, Biomedical and Clinical Applications”, John Wiley & Sons, Inc, 1990, pp. 327-347.

K. Taghizadeh, B.H. Davis, W. Windig and H.L.C. Meuzelaar, Off-line process monitoring of coal-derived liquid fuels by computer-assisted low-voltage mass spectrometry, Novel techniques in fossil fuel mass spectrometry, ASTM STP 1019, T.R. Ashe and K.V. Woods, Eds, American Society for Testing and Materials, Philadelphia, 1989, pp. 144-158.

T. Chakravarty, H.L.C. Meuzelaar, W. Windig and G.R. Hill, Time-Resolved Pyrolysis Mass Spectrometry of Coal: A New Tool for Mechanistic and Kinetic Studies. ACS Reprints (Div. of Fuel Chem.) Vol. 32, No. 3, 1987, pp. 211-216.

B.L. Hoestery, W. Windig, H.L.C. Meuzelaar, E.M. Eyring, D.M. Grant and R.M. Pugmire, An Integrated Spectroscopic Approach to Chemical Characterization of Pyrolysis Oils, ACS Reprints (Div. of Fuel Chem.) Vol. 32, 2, 1987, pp. 195-202.

W. Windig and H.L.C. Meuzelaar, Numerical Extraction of Components from Mixture Spectra by Multivariate Data Analysis, in H.L.C. Meuzelaar, T.L. Meuzelaar (eds.), “Computer-enhanced Analytical Spectroscopy”, Plenum Publishing Co., New York, 1987, pp. 67-102.

H.L.C. Meuzelaar, W. Windig, J.H. Futrell and S.R. Larter, Pyrolysis Mass Spectrometry and Multivariate Analysis of Some Key World Oil Shale Kerogens and Some Recent Alginites, ASTM STP 902 1986, pp. 81-105.

B.L. Hoesterey, W.H. McClennen, W. Windig and H.L.C. Meuzelaar, Computer Enhanced Separation of Compound Classes in Fuel Mixtures Using a Combined LC-MS Approach, ACS Reprints (Div. of Fuel Chem.) Vol. 30, No. 4, 1985, pp. 85-92.

H.L.C. Meuzelaar, W. Windig and G.S. Metcalf, Numerical Extraction of Chemical Component Patterns from Pyrolysis Mass Spectra of U.S. Lignites, ACS Reprints (Div. of Fuel Chem.) Vol. 30, No. 1, 1985, pp. 200-208.

A.C.M. Weijman, G.W. Van Eijk, W. Windig and R.A. Samsom, Methods for the Mycological Examination of Food, in A.D. King, J.I. Pitt, L.R. Beuchat and J.E.L. Corry (eds.), “Modern Detection Methods for Food Spoilage Fungi”, Proceedings of NATO Advanced Research Workshop on Standardization of Methods for the Mycological Examination of Foods, July 11-13, 1984, Boston, Massachusetts.

H.L.C. Meuzelaar, W.H. McClennen, C.C. Cady, G.S. Metcalf, W. Windig, J.R. Thurgood and G.R. Hill, Pyrolysis Mechanisms and Weathering Phenomena in Rocky Mountain Coals, ACS Reprints (Div. of Fuel Chem.) Vol. 29, No. 5, 1984, pp. 166-177.