Bob Roginski, Ph.D.

Technology Principal
Eigenvector Research, Inc.

1930 Abbotsbury Way
Lafayette, IN 47909
phone: (765) 337-8497
e-mail: roginski@eigenvector.com

Education:

Ph.D. Chemical Engineering, University of Illinois, 1987. M.S. Chemical Engineering, University of Illinois, 1987. B.S. Chemical Engineering, University of Illinois at Chicago, 1983.

Experience:

June 2006-present, Senior Applications Scientist, Eigenvector Research, Inc.

September 2003-May 2006, Principal Research Scientist, Eli Lilly & Co. Late stage development engineer for active pharmaceutical ingredient. Jointly managed Process Technology Laboratory, which combined on-line analytical instrumentation with controlled reactors of various scales to provide extensive process understanding. Identified on-line analytical measurement and control technologies to support API development, characterization, scale-up and technology transfer activites..

October 1999-July 2003, Process Analytical Engineer, Pfizer/Pharmacia/Searle. Process analytical technology (PAT) engineer specializing in applying optical spectroscopies for developing robust chemical processes. Identify, develop and implement on-line/at-line analytical measurement and control technology to support active pharmaceutical ingredient (API) process development, characterization, scale-up and transfer activities. Support life cycle management in the maintenance and updating of on-line/at-line analytical measurement and control technology. Determine process stability criteria through the means of on-line measurements. Provide technical leadership in evaluating new process analytical technology for future implementation.

November 1989-October 1999, Research Engineer, Amoco Corporation (Corporate Research Center). Provide analytical spectroscopy support to R&D staff and operating plants and refineries. Areas of expertise include: Infrared spectroscopy, infrared microscopy, Raman spectroscopy, UV-visible spectroscopy, thermal-IR and UV-visible spectroscopy, catalyst characterization, chemometrics, computer programming for scientific applications (Array Basic, C, and MATLAB) and mathematical methods as applied to spectroscopy. Directed effort to expand areas of expertise for work unit, including IR-microscopy, TGA-FTIR, FT-Raman spectroscopy, and fluorescence spectroscopy. .

Professional Organizations:

American Chemical Society, American Institute of Chemical Engineers, Society of Applied Spectroscopy (chairperson of Workshop Committee 1996-9, Chicago Section, Instrument Society of America, Tau Beta Pi (Engineering Honor Society), Phi Kappa Phi

Publications:

M.D. Argentine, T.M. Braden, J. Czarnik, E.W. Conder, S.E. Dunlap, J.W. Fennell, M.A. LaPack, R.R. Rothhaar, R.B. Scherer, C.R. Schmid, J.T. Vicenzi, J.G. Wei, J.A. Werner, and R.T. Roginski, “The Role of New Technologies in Defining a Manufacturing Process for PPARa Agonist LY518674,” Org. Process Res. Dev. 2009, 13(2), 131-143.

P. D. Hopkins, J. T. Miller, B. L. Meyers, G. J. Ray, R. T. Roginski, M. A. Kuehne, and H. H. Kung, “Acidity and Cracking Activity Changes During Coke Deactivation of Ultrastable Y Zeolite”, , Appl. Catal., A (1996), 136(1), 29-48.

D. E. Fjare and R. T. Roginski, “IR Studies of Polyamic Acid Curing: Solvent Effects”, Adv. Polyimide Sci. Technol. Proc. Int. Conf. Polyimides, 4th (1993), 326-35.

B. O. Budevska, C J. Manning, P. R. Griffiths, and R. T. Roginski, “Step-Scan Fourier Transform Infrared Study on the Effect of Dynamic Strain on Isotactic Polypropylene”, Appl. Spectrosc. (1993), 47(11), 1843-51.

I. Puskas, T.H. Fleisch, J.B. Hall, B.L. Meyers, R.T. Roginski,”Cobalt reducibility and magnesium promotion in silica-supported Fischer-Tropsch catalysts”, Stud. Surf. Sci. Catal. (1993), 75 (New Frontiers in Catalysis, Pt. C), 2813-16.

J. T. Miller, P. D. Hopkins, B. L. Meyers, G. J. Ray, R. T. Roginski, G. W. Zajac, and N. H. Rosenbaum, “The Effect of Non-Framework Aluminum on Acidity in Dealuminated Mordenites”, J. Catal. (1992), 138(1) 115-28.

S. M. Fatemi-Badi, A. Swanson, N. K. Sethi, and R. T. Roginski, “Characterization of Martin Lake Lignite and Its Residue After Liquefaction”, Am. Chem. Soc. Div. Fuel Chem. 36(2), 470 (1991).

I. Puskas, T. H. Fleisch, J. B. Hall, B. L. Meyers, and R. T. Roginski, “Metal Support Interactions in Precipitated, Magnesium-Promoted Cobalt-Silica Catalysts”, J. Catal. 134, 615-28 (1992).

J. M. Salley, C. W. Frank, T. Miwa, and R. T. Roginski, “Charge Transfer in Polyimides”, Adv. Polyimide Technol., Proc. Int. Conf. Polyimides, 4th (1993), 441-50.

D. E. Fjare and R. T. Roginski, “Cure Studies of Fluorinated Polyamic Acids by Thermal-IR”, Mater. Res. Soc. Symp. Proc. (1992), 264 (Electronic Packaging Materials Science VI), 123-34.

A. J. Beuhler, M. J. Burgess, D. E. Fjare, J. M. Gaudette, and R. T. Roginski, “Moisture and Purity in Polyimide Coatings”, in “Electronic Packaging Materials Science IV”, Materials Research Society Symposium Proceedings, vol. 154, R. Jacodine, K. A. Jackson, E. D. Lillie, and R. C. Sundahl, eds., 73-90 (1989).

J. L. Coffer, H. G. Drickamer, J. T. Park, R. T. Roginski, & J. R. Shapley, “Infrared Spectra of C2 Hydrocarbon Ligands Coordinated to a Triosmium Framework: The Effect of High Pressure as a Tool for Assignment”, J. Phys. Chem. (1990), 94(5), 1981-5.

R. T. Roginski, T. L. Carroll, A. Moroz, B. R. Whittlesey, J. R. Shapley, and H. G. Drickamer, “High-Pressure Spectroscopic Studies of Dihalo- tetrakis (pivalato) dirhenium(III) Metal-Metal Quadruply Bonded Complexes, Inor. Chem. 27, 3701-6 (1988).

R. T. Roginski, J. R. Shapley, and H. G. Drickamer, “High-Pressure Spectroscopic Studies of Ferrocene, Nickelocene, and Ruthenocene”, J. Phys. Chem. 92, 4316-4319 (1988).

R. T. Roginski, A. Moroz, D. N. Hendrickson, and H. G. Drickamer, “Pressure Tuning of the Electronic Energy Levels of Ferrocene, Cobaltocenium Hexafluorophosphate, and Nickelocene”, J. Phys. Chem. 92, 4319-4323 (1988).

R. T. Roginski, A. M. Moroz, and H. G. Drickamer, “High Pressure Spectroscopic Study of Ferricenium Hexafluorophosphate: Pressure-Induced Order-Disorder Transitions”, Chem. Phys. Lett. 143, 577-579 (1988).

R. T. Roginski, J. R. Shapley, H. G. Drickamer, and M. J. D’Aniello, “Pressure Tuning Spectroscopy of [[Pt3 [CO]6] 2-]n, n=3-5”, Chem. Phys. Lett. 135, 525-528 (1987).

R. T. Roginski, J. R. Shapley, and H. G. Drickamer, “Pressure Tuning of Electronic States of Cs3Re3Cl12”, Chem. Phys. Lett. 127, 185-188 (1986).

Selected Presentations:

“Applications of Process Analytical Technologies to Ensure Controlled Processes”, Mark A. LaPack, Robert T. Roginski, Amanda McDaniel, Steven J. Doherty, and Daniel Creeden, accepted for AIChE Annual Meeting, 2006.

“Feedforward Modeling Approach to Particle Size Control in Milling Operations”, Paul C. Collins and Robert T. Roginski, accepted for AIChE Annual Meeting, 2006.

“The Value of Characterizing the Reaction Gas Phase in Pharmaceutical Process Development Experiments”, Mark A. LaPack, Steven J. Doherty, Amanda McDaniel, Robert T. Roginski, Jodi Czarnik, FACSS 2005

“Optimization in the Drug Substance Development Factory”, Robert T. Roginski and Mark A. LaPack, invited talk at Cambridge Healthtech Institute, 2005.

“Process Spectroscopy in Pharmaceutical API Development”, Robert T. Roginski, invited talk to Purdue Dept. of Chemical Engineering graduate seminar, 2005.

“Creating Knowledge from Data: Applications of Chemical Process Development”, Paul A. David, Robert T. Roginski, Steven J. Doherty, FACSS 2002.

“On-Line Analytical Technologies: Increasing Efficiency in Pharmaceutical Process Development and Plant Support”, Steven J. Doherty, Robert T. Roginski, Mark A. LaPack, and Paul A. David, IFPAC 2002.

“Integrated Analytical Technology: Instrumental in Achieving Efficient Pharmaceutical Process Development”, Steven J. Doherty, Mark A. LaPack, Paul A. David, Robert T. Roginski, Shan Lin, Nicolas J. Kosiara, Linda S. Bailey, Fernando Del Castillo, Tony A. Sain, Paul M. Gutierrez, Chung C. Kim, ACS Analytical Division, Fall 2001.

“Utilization of In-situ IR for Process Characterization and Control of Active Pharmaceutical Ingredient Manufacture”, R. T. Roginski and P. A. David, presented at ASI Reaction Engineering Users Forum 2000, Captiva Island FL 2000.

“Evaluation of In-situ Analytical Technology for Process Monitoring of ASBT Step 11”, R. T. Roginski, presented at TCM Tech 2000, St. Louis 2000.

“Utilization of the Integrated Development Laboratories for Valdecoxib Scale-Up and Technology Transfer”, P. A. David, D. Gallagher, J. Weisenburger, J. Moe, S. J. Doherty, S. Lin, C. Kim, M. A. LaPack. R. T. Roginski, J. Flahive, and P. Mudipalli, presented at TCM Tech 2000, St. Louis 2000.

“Strategy for the Development of an IR Method for Control of API Manufacture”, P. A. David, S. J. Doherty, R. T. Roginski, L. Letendre, G. Danzer and S. Lin, presented at the International Forum on Process Analytical Chemistry, IFPAC, Lake Las Vegas NV 2000.

“Making It Work: A Chronological Tale of an On-line Analyzer”, R. T. Roginski, invited talk presented at the Eastern Analytical Symposium, New Jersey 1999.

“Spectrochemical Analysis: From Academic Research to Industrial Process Monitoring and Control”, G. H. Vickers, M. J. Rutledge, R. T. Roginski, and K. W. Andresen, presented at the 216th ACS National Meeting, Boston 1998.

“On-line Analyzers: What the Vendors Don’t Tell You”, R. T. Roginski, presented at Midwest Process Analytical Vendor Forum, 1995

“Metal-Support Interactions in Precipitated, Magnesium-Promoted Cobalt-Silica Catalysts”, I. Puskas, J. B. Hall, T. H. Fleisch, B. L. Meyers, and R. T. Roginski, presented at the International Conference on Catalysis, Budapest, Hungary, July 1992.

“Cure Studies of Fluorinated Polyamic Acids by Thermal-IR”, D. E. Fjare and R. T. Roginski, presented at the Spring 1992 Materials Research Society Meeting, San Francisco, May 1992.

“Infrared Studies of Polyamic Acid Curing: Solvent Effects”, D. E. Fjare and R. T. Roginski, presented at the Fourth International Conference on Polyimides, Ellenville, NY, November 1991.

“An Analytical and Catalytic Characterization of Dealuminated Mordenites”, B. L. Meyers, J. T. Miller, P. D. Hopkins, G. J. Ray, R. T. Roginski, N. H. Rosenbaum, and G. W. Zajac, presented at the 12th North American Catalyst Symposium, 1991.