EVRI-thing You Need to Know About Lean Chemometrics in PLS_Toolbox/Solo 9.6
The 9.6 version of PLS_Toolbox and Solo was released in September, 2026. In this release we introduce a new suite of tools for Lean Chemometrics including Iterative Optimization Technology (IOT) and Indirect IOT (IIOT, aka extended IOT). These methods reduce the calibration burden for new spectroscopic applications, especially for PAT in pharma. This video shows you how to use the new tools and show how they relate to Classical Least Squares (CLS) methods.
This webinar is part of a series of webinars that take deeper dives into all the new features of PLS_Toolbox/Solo 9.6 with a focus on use cases and “how to”.
The slides for the presentation may be found here.
Table of Contents
00:00 Welcome & Outline
01:21 What Is Lean Chemometrics? — Goals & the Calibration Burden
03:51 Theory: From Pure Component Spectra to IOT/CLS Models
09:21 Geometric Interpretation & Simulation Study (IOT vs. CLS+1-Norm)
20:09 Hands-On: IOT Interface Demo (building models, diagnostics, diluted sample)
32:10 Volume Fraction vs. Weight Fraction — Explaining Model Bias
39:47 Practical Considerations & Batch Monitoring
43:39 Summary & Q&A
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