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Willem Windig , Ph.D.
Chief
Eigenspectroscopist ,
Eigenvector Research, Inc.
3905 West Eaglerock Drive
Wenatchee, WA 98801
phone: (585)621-0628
fax: (509) 687-7033
e-mail: windig@eigenvector.com |
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Education:
A.S.,
Fine Arts, with distinction, 2000, Monroe Community College, Rochester,
NY
Ph.D.,
Biology and Physics, 1982 University of Utrecht, The Netherlands
M.S., Biology and Physics, with teacher certification, 1977 University
of Amsterdam, The Netherlands
B.S., Biology and Physics, 1973 University of Amsterdam, The Netherlands
Experience:
Research
Associate, 1994-2002, Senior Scientist, 1988-1994, Eastman Kodak
Company, Rochester, NY
Senior Scientist I, 1987-1988 Geo Centers Inc., Ft. Washington,
Maryland
Senior Research Associate 1985-1987 Postdoctoral fellow 1982-1985
Biomaterials Profiling Center University of Utah, Salt Lake City,
Utah
Research Interests:
Development
of multivariate data analysis techniques and their application to
solve actual problems. Development of user-friendly software to
apply these techniques.
Honors:
Member
of editorial advisory board of 'Chemometrics and Intelligent Laboratory
Systems'.
Patents:
R. Schweitzer, P.J. Treado, W. Windig, "Method for Identifying Components of a Mixture via Spectral Analysis," US Patent 7,072,770, July 4, 2006.
W.
Windig, "Method for Comparison of Similar Samples in Liquid Chromatography/Mass
Spectrometry, US Patent 6,329,652 B1," Dec. 11, 2001.
W.
Windig and B. Antalek, "Image Analysis Using the Direct Exponential
Curve Resolution Algorithm, U.S. Patent 5,841,891," Nov. 24, 1998.
W.
Windig and A.W. Payne, "Noise and Background Reduction Method for
Component Detection in Chromatography/Spectrometry," US Patent 5.672,896,
Sep. 30, 1997.
W.
Windig, "Apparatus for Interactive Self-Modeling Mixture Analysis,"
US Patent 5,481,476, Jan. 2, 1996.
Publications (refereed journals):
W. Windig, J.M. Shaver and R. Bro, Loopy MSC, a Simple Way to Improve Multiplicative Scatter Correction, Applied Spectroscopy, October 2008, in press.
W.
Windig, B.Antalek, J.L. Lippert, Y. Batonneau and C. Bremard, Combined
Use of Conventional and Second-derivative Data in the SIMPLISMA
Self-modeling Mixture Analysis Approach, Anal. Chem., in press.
N.B. Gallagher, J.M. Shaver, W. Windig, T.A. Blake, and P.L. Gassman, "Multivariate Curve Resolution Applied to Infrared Reflectance Measurements of Soil Contaminated with Organic Analyte" Appl. Spectrosc., 60(7), 713-722 (2006).
W. Windig, N.B. Gallagher, J.M. Shaver and B.M. Wise, " New Approach for Interactive Self-Modeling Mixture Analysis," Chemometr. Intell. Lab., 77(1-2), 85-96 (2005).
N.B. Gallagher, J.M Shaver, E.B. Martin, J. Morris, B.M. Wise and W.Windig, Curve resolution for images with applications to TOF-SIMS and Raman, Chemometrics and Intelligent Laboratory Systems 77, 2003, 105-117.
B. Antalek, J.M Hewitt, W. Windig. P.D. Yacobucci, T. Mourey and Kim Le, The use of PGSE NMR and DECRA for determining polymer composition, Mag. Reson. in Chem., 40, 2002, S60-S71.
W.
Windig, W.F. Smith, W.F. Nichols, Fast Interpretation of Complex
LC/MS Data Using Chemometrics, Anal. Chim. Act 446, 2001, 467-476.
W.
Windig, B. Antalek, M.J. Robbins, N. Zumbulyadis and C.E. Heckler,
Applications of the Direct Exponential Curve Resolution Algorithm
(DECRA) to Solid State Nuclear Magnetic Resonance and Mid-infrared
Spectra, J. Chemometrics, 14, 2000, 213-227.
N.
Zumbulyadis, B. Antalek, W. Windig, R.P. Scaringe, A.M. Lanzafame,
T. Blanton and M. Helber, Elucidation of Polymorph Mixtures Using
Solid-State 13C CP/MAS NMR Spectroscopy and Direct Exponential Curve
Resolution Algorithm, JACS, 121, 1999, 11554-11557.
W.
Windig, B. Antalek, L.J. Sorriero, S. Bijlsma, D.J. Louwerse and
A.K. Smilde, Applications and New Developments of the Direct Exponential
Curve Resolution Algorithm (DECRA). Examples of Spectra and Magnetic
Resonance Images, J. Chemom., 13, 1999, 95-110.
S.
Bijlsma, D.J. Louwerse, W. Windig and A.K. Smilde, Rapid Estimation
of Rate Constants Using On-line SW-NIR and Trilinear Models, Anal.
Chim. Act., 376, 1998, 339-355.
W.
Windig and B. Antalek, Resolving Nuclear Magnetic Resonance Data
of Mixtures by 3-way analysis. Examples of Chemical Solutions and
the Human Brain, Chemom. and Intell. Lab. Syst., 46, 1999, 207.
W.
Windig, J.P. Hornak and B. Antalek, Multivariate Analysis of Magnetic
Resonance Images with the Direct Exponential Curve Resolution Algorithm
(DECRA), Part 1: Algorithm and Model Study, JMR, 132, 1998, 298-306.
B.
Antalek, J.P. Hornak and W. Windig, Multivariate Analysis of Magnetic
Resonance Images with the Direct Exponential Curve Resolution Algorithm
(DECRA), Part 2: Application to Human Brain Images, JMR, 132, 1998,
307-135.
W.
Windig and B. Antalek, Direct Exponential Curve Resolution (DECRA):
A Novel Application of the Generalized Rank Annihilation Method
for a Single Spectral Mixture Data Set with Exponentially Decaying
Profiles, Chemometrics and Intelligent Laboratory Systems, 37, 1997,
241-254.
W.
Windig, Spectral Data Files for Self-Modeling Curve Resolution with
Examples Using the SIMPLISMA Approach, Chemometrics and Intelligent
Laboratory Systems, 36, 1997, 3-16.
W.
Windig, J.M. Phalp and A.W. Payne, A Noise and Background Reduction
Method for Component Detection in Liquid Chromatography/Mass Spectrometry,
Anal. Chem., 68, 1996, 3602-3603.
B.
Antalek and W. Windig, Generalized Rank Annihilation Method Applied
to a Single Multicomponent Pulsed Gradient Spin Echo NMR Data set,
J. Am. Chem. Soc., 118, 1996, 10331-10332.
J.M.
Phalp, A.W. Payne and W. Windig, The Resolution of Mixtures Using
Data from Automated Probe Mass Spectrometry, Anal. Chim. Act., 318,1995,
43-53.
W.
Windig, D.E. Margevich and W.P. McKenna, A Novel Tool for Two-Dimensional
(2D) Correlation Spectroscopy, Chemometrics and Intelligent Laboratory
Systems, 28, 1995, 108-128.
W.
Windig, The Use of Second-Derivative Spectra for Pure-Variable Based
Self-Modeling Mixture Analysis Techniques, Chemometrics and Intelligent
Laboratory Systems, 23, 1994, 71-86.
J.
Guilment, S. Markel and W. Windig, Infrared Chemical Micro-Imaging
Assisted by Interactive Self-Modeling Multivariate Analysis, Appl.
Spectr., 48, 1994, 320-326.
W.
Windig and S. Markel, Simple-to-Use Interactive Self-Modeling Mixture
Analysis of FTIR Microscopy Data, J. Mol. Struct., 292, (1993),
161-170.
W.
Windig, Self-Modeling Mixture Analysis of Spectral Data with Continuous
Concentration Profiles, Chemometrics and Intelligent Laboratory
Systems, 16, 1992, 1-16.
W.
Windig and D.A. Stephenson, Self-Modeling Mixture Analysis of Second-Derivative
Near Infrared Spectral Data Using the SIMPLISMA Approach, Anal.
Chem., 62, 1992, 2735-2742.
W.
Windig, C.E. Heckler, F.A. Agblevor and R.J. Evans, Self-Modeling
Mixture Analysis of Categorized Pyrolysis Mass Spectral Data with
the SIMPLISMA Approach, Chemometrics and Intelligent Laboratory
Systems, 14, 1992, 195-206.
W.
Windig and J. Guilment, Interactive Self-Modeling Mixture Analysis,
Anal. Chem., 63, 1991, 1425-1432.
A.P.
Snyder, W. Windig and J.P. Toth, Interactive Self-Modeling Multivariate
Analysis of Thermolysis Mass Spectra, Chemometrics and Intelligent
Laboratory Systems, 11, 1991, 149-160.
W.
Windig, J.L. Lippert, M.J. Robbins, K.R. Kresinske, J.P. Twist and
A.P. Snyder, Interactive Self-Modeling Multivariate Analysis, Chemometrics
and Intelligent Laboratory Systems, 9, 1990, 7-30.
W.
Windig, Mixture Analysis of Spectral Methods by Multivariate Methods,
Chemometrics and Intelligent Laboratory Systems, 9, 1990, 7-30.
M.
Nip, J.W. de Leeuw, P.A. Schenck, W. Windig, H.L.C. Meuzelaar and
J.C. Crelling, A Flash Pyrolysis Petrographic Study of Cutinite
from the Indiana Paper Coal, Geochim. et Cosmochim. Acta, 53, 1989,
671-683.
W.
Windig, S.A. Liebman, M.B. Wasserman and A.P. Snyder, Fast Self-Modeling
Curve Resolution Method for Time Resolved Mass Spectral Data, Anal.
Chem., 60, 1988, 1503-1509.
A.P.
Snyder, J.H. Kremer, H.L.C. Meuzelaar and W. Windig, Curie-Point
Pyrolysis Atmospheric Pressure Chemical Ionization Mass Spectrometry
as a Probe on the Effect of Sodium Chloride on Biopolymers, J. Anal.
Appl. Pyr., 13, 1988, 77-88.
A.P.
Snyder, G.A. Eiceman and Willem Windig, Influence of Pyrolytic Techniques
on Mass Spectra of Biopolymers with Chemical Ionization at Atmospheric
Pressure, J. Anal. Appl. Pyrol, 13, 1988, 243-257.
E.
Jakab, B.L. Hoesterey, W. Windig, G.R. Hill and H.L.C. Meuzelaar,
Effects of Low Temperature Air Oxidation (Weathering) Reactions
on the Pyrolysis Mass Spectra of U.S. Coals, Fuel, 67, 1988, 73-80.
W.
Windig, E. Jakab, J.M. Richards and H.L.C. Meuzelaar, Self-Modeling
Curve Resolution by Factor Analysis of a Continuous Series of Pyrolysis
Mass Spectra, Anal. Chem., 59, 1987, 317-323.
G.S.
Metcalf, W. Windig, G.R. Hill and H.L.C. Meuzelaar, Characterization
of U.S. Lignites by Pyrolysis Mass Spectrometry and Multivariate
Analysis, Coal Geology, 7, 1987, 245-268.
W.
Windig, W.H. McClennen and H.L.C. Meuzelaar, Determination of Fractional
Concentrations and Exact Component Spectra by Factor Analysis of
Pyrolysis Mass Spectra of Mixtures, Chemometrics and Intelligent
Laboratory Systems, 1, 1987, 151-165.
A.P.
Snyder, J.H. Kremer, W. Windig, H.L.C. Meuzelaar and K. Taghizadeh,
Curie-point Pyrolysis Atmospheric Pressure Chemical Ionization Mass
Spectrometry: Preliminary Performance Data for Three Biopolymers,
Anal. Chem., 59, 1987, 1945-1951.
H.L.C.
Meuzelaar, B.L. Hoesterey, W. Windig and G.R. Hill, Prediction and
Modeling of Coal Conversion Reactions by Pyrolysis Mass Spectrometry
and Multivariate Statistical Analysis, Fuels Processing Technology,
15, 1987, 59-70.
T.
Chakravarty, W. Windig, K. Taghizadeh, H.L.C. Meuzelaar and L.J.
Shadle, Computer-Assisted Interpretation of Pyrolysis Mass Spectra
of Two Oil Shales and their Corresponding Kerogens, Energy and Fuels,
2, 1986, 191-196.
H.L.C.
Meuzelaar, W. Windig, S.M. Huff and J.M. Richards, Process Monitoring
and Quality Assurance of Polymeric Materials by Computerized Pyrolysis
Mass Spectrometry, Anal. Chim. Act., 190, 1986, 119-132.
W.
Windig, T. Chakravarty, J.M. Richards and H.L.C. Meuzelaar, Multivariate
Analysis of Time-Resolved Mass Spectral Data, Anal. Chim. Act.,
191, 1986, 205-218.
W.
Windig, W.H. McClennen, H. Stolk and H.L.C. Meuzelaar, Unsupervised
Chemical Pattern Recognition in Complex Mass Spectra, Optical Engineering,
25, 1986, 117-122.
S.M.
Huff, J.M. Matsen, W. Windig and H.L.C. Meuzelaar, Pyrolysis Mass
Spectrometry of Bacteria from Infected Human Urine: I. Influence
of Culturing and Antibiotics, Biomedical and Environmental Mass
Spectrometry, 13, 1986, 277-286.
J.L.
Savoca, R.P. Lattimer, J.M. Richards, W. Windig and H.L.C. Meuzelaar,
Pyrolysis Mass Spectrometry Correlations of Crosslink Density in
Natural Rubber Vulcanizates, J. Anal. Appl. Pyrol., 9, 1985, 19-28.
R.P.
Lattimer, K.M. Schur, W. Windig and H.L.C. Meuzelaar, Quantitative
Analysis of Rubber Triblends by Pyrolysis Mass Spectrometry, J.
Anal. Appl. Pyrol., 8, 1985, 95-107.
H.L.C.
Meuzelaar, W. Windig, A.M. Harper, S.M. Huff, W.H. McClennen and
J.M. Richards, Pyrolysis Mass Spectrometry of Complex Organic Materials,
Science, 226, 1984, 268-274.
A.C.M.
Weyman, G.W. van Eijk, H.J. Roeijmans, W. Windig, J. Haverkamp and
L.J. Turkensteen, Mass Spectrometric Techniques as Aids in the Diagnosis
of Gangrene in Potatoes Caused by Phoma exigua var. foveata, (Forster)
Boerema, Neth. J. Pl. Path., 90, 1984, 107-115.
G.
Halma, D. van Dam, J. Haverkamp, W. Windig and H.L.C. Meuzelaar,
Characterization of an Oligotrophic-Eutrophic Peat Sequence by Pyrolysis
Mass Spectrometry and Conventional Analysis Methods, J. Anal. Appl.
Pyrol., 7, 1984, 167-183.
W.
Windig, H.L.C. Meuzelaar, F. Shafizadeh and R.G. Kelsey, Biochemical
Analysis of Wood and Wood Products by Pyrolysis Mass Spectrometry
and Multivariate Analysis, J. Anal. Appl. Pyrol., 6, 1984, 233-250.
W.
Windig and H.L.C. Meuzelaar, Nonsupervised Numerical Extraction
from Pyrolysis Mass Spectra of Complex Mixtures, Anal. Chem., 56,
1984, 2297-2303.
H.L.C.
Meuzelaar, S.M. Huff, W. Windig and P. Kenemans, Pyrolyse Massaspektrometrie
in Klinisch-Chemisch Perspectief, Tijdschrift NVKC, 1984, 47-52.
W.
Windig, H.L.C. Meuzelaar and M. Jacobson, Embryos of Xenopis Leavis
as a Model for Pyrolysis Mass Spectrometry Studies, J. Anal. Appl.
Pyrol., 5, 1983, 349-362.
W.
Windig, H.L.C. Meuzelaar, B.A. Haws, W.F. Campbell and K.H. Asay,
Biochemical Differences in Pyrolysis Mass Spectra of Range Grasses
with Different Resistance to Labops Hesperius (Uhler) Attack, J.
Anal. Appl. Pyrol., 2, 1983, 183-198.
J.J.
Boon, W. Windig, R.G. Wetzel and G.L. Godshalk, Analysis of Particulate
Organic Matter from Myriophyllum by Pyrolysis Mass Spectrometry,
Aquat. Bot. 15, 1983, 307-320.
W.
Windig, J.Haverkamp and P.G. Kistemaker, Chemical Interpretation
of Sets of Pyrolysis Mass Spectra by Discriminant Analysis and Graphical
Rotation, Anal. Chem. 55, 1983, 81-88.
W.
Windig, H.L.C. Meuzelaar and J. Haverkamp, Pyrolysis Mass Spectrometry
of Virus-Infected Plants and Fungi, Phytopathology, Proc. C 86 (3),
1983, 437-444.
W.
Windig and G.S. de Hoog, Pyrolysis Mass Spectrometry, I. Sporidiobolus,
Stud. Mycol., 22, 1982, 60-64.
W.
Windig and J. Haverkamp, Pyrolysis Mass Spectrometry, I. Rhodosporidium,
Stud. Mycol., 22, 1982, 56-59.
W.
Windig, P.G. Kistemaker and J.Haverkamp, Chemical Interpretation
of Differences in Pyrolysis Mass Spectra of Simulated Mixtures of
Biopolymers by Factor Analysis with Graphical Rotation, J. Anal.
Appl. Pyrol., 3, 1981, 199-212.
D.
van de Meent, J.W. de Leeuw, P.A. Schenck, W. Windig and J. Haverkamp,
Quantitative Analysis of Biopolymers Mixtures by Pyrolysis Mass
Spectrometry, J. Anal. Appl. Pyrol., 2, 1982, 133-142.
W.
Windig, G.S. de Hoog and J. Haverkamp, Chemical Characterization
of Yeasts and Yeast-like Fungi by Factor Analysis of their Pyrolysis
Mass Spectra, J. Anal. Appl. Pyrol., 2, 1981, 213-220.
W.
Windig, J. Haverkamp and A.L. van Wezel, Control on the Absence
of DEAE-Polysaccharides in DEAE-Sephadex Purified Poliovirus Suspensions
by Pyrolysis Mass Spectrometry, Develop. Biol. Standard. 47, 1980,
169-177.
W.
Windig, P.G. Kistemaker, J. Haverkamp and H.L.C. Meuzelaar, Factor
Analysis of the Influence of Changes in Experimental Conditions
in Pyrolysis Mass Spectrometry, J. Anal. Appl. Pyrol., 2, 1980,
7-18.
J.
Haverkamp, P.G. Kistemaker, A.J.H. Boerboom, W. Eshuis, G. Wieten
and W. Windig, Toepassingen van Pyrolyse Massaspectrometrie in de
Klinische Chemie, Mededelingen Ned. Ver. voor Klinische Chemie,
4, 1979, 188-202.
W.
Windig, P.G. Kistemaker, J. Haverkamp and H.L.C. Meuzelaar, The
Effects of Sample Preparation, Pyrolysis and Pyrolyzate Transfer
Conditions on Pyrolysis Mass Spectra, J. Anal. Appl. Pyrol., 1,
1979, 39-52.
Publications (book chapters and full length
proceedings):
W. Windig, S. Markel and P.M. Thompson, Self-modeling Image Analysis with SIMPLISMA, in H.F. Grahn and P. Geladi (eds.) , “Techniques and Applications of Hyperspectral Image Analysis”, John Wiley & Sons, Ltd, 2007, pp. 69-88
B. Antalek, W. Windig and J.P. Hornak, Multivariate Image Analysis of Magnetic Resonance Images: Component Resolution with the Direct Exponential Curve Resolution Algorithm (DECRA), in H.F. Grahn and P. Geladi (eds.) , “Techniques and Applications of Hyperspectral Image Analysis”, John Wiley & Sons, Ltd, 2007, pp. 261-288.
W.
Windig, Mixture Analysis of Spectral Data by Multivariate Methods,
in D.L. Massart, R.G. Brereton, R.E. Dessy, P.K. Hopke, C.H. Spiegelman,
W. Wegscheider (eds.), "Chemometrics Tutorials", Elsevier, 1990,
pp. 293-305.
W.
Windig, A Simple-to-use Method for Interactive Self-Modeling Mixture
Analysis, in P.C. Jurs (ed). "Computer-Enhanced Analytical Spectroscopy",
Volume 3, Plenum Press, New York, 1992, pp. 67-102.
G.A.
Eiceman, W. Windig and A.P. Snyder, Gas Chromatography of Microorganisms,
in R.E. Clement (ed.), "Gas Chromatography: Biochemical, Biomedical
and Clinical Applications", John Wiley & Sons, Inc, 1990, pp. 327-347.
K.
Taghizadeh, B.H. Davis, W. Windig and H.L.C. Meuzelaar, Off-line
process monitoring of coal-derived liquid fuels by computer-assisted
low-voltage mass spectrometry, Novel techniques in fossil fuel mass
spectrometry, ASTM STP 1019, T.R. Ashe and K.V. Woods, Eds, American
Society for Testing and Materials, Philadelphia, 1989, pp. 144-158.
T.
Chakravarty, H.L.C. Meuzelaar, W. Windig and G.R. Hill, Time-Resolved
Pyrolysis Mass Spectrometry of Coal: A New Tool for Mechanistic
and Kinetic Studies. ACS Reprints (Div. of Fuel Chem.) Vol. 32,
No. 3, 1987, pp. 211-216.
B.L.
Hoestery, W. Windig, H.L.C. Meuzelaar, E.M. Eyring, D.M. Grant and
R.M. Pugmire, An Integrated Spectroscopic Approach to Chemical Characterization
of Pyrolysis Oils, ACS Reprints (Div. of Fuel Chem.) Vol. 32, 2,
1987, pp. 195-202.
W.
Windig and H.L.C. Meuzelaar, Numerical Extraction of Components
from Mixture Spectra by Multivariate Data Analysis, in H.L.C. Meuzelaar,
T.L. Meuzelaar (eds.), "Computer-enhanced Analytical Spectroscopy",
Plenum Publishing Co., New York, 1987, pp. 67-102.
H.L.C.
Meuzelaar, W. Windig, J.H. Futrell and S.R. Larter, Pyrolysis Mass
Spectrometry and Multivariate Analysis of Some Key World Oil Shale
Kerogens and Some Recent Alginites, ASTM STP 902 1986, pp. 81-105.
B.L.
Hoesterey, W.H. McClennen, W. Windig and H.L.C. Meuzelaar, Computer
Enhanced Separation of Compound Classes in Fuel Mixtures Using a
Combined LC-MS Approach, ACS Reprints (Div. of Fuel Chem.) Vol.
30, No. 4, 1985, pp. 85-92.
H.L.C.
Meuzelaar, W. Windig and G.S. Metcalf, Numerical Extraction of Chemical
Component Patterns from Pyrolysis Mass Spectra of U.S. Lignites,
ACS Reprints (Div. of Fuel Chem.) Vol. 30, No. 1, 1985, pp. 200-208.
A.C.M.
Weijman, G.W. Van Eijk, W. Windig and R.A. Samsom, Methods for the
Mycological Examination of Food, in A.D. King, J.I. Pitt, L.R. Beuchat
and J.E.L. Corry (eds.), "Modern Detection Methods for Food Spoilage
Fungi", Proceedings of NATO Advanced Research Workshop on Standardization
of Methods for the Mycological Examination of Foods, July 11-13,
1984, Boston, Massachusetts.
H.L.C.
Meuzelaar, W.H. McClennen, C.C. Cady, G.S. Metcalf, W. Windig, J.R.
Thurgood and G.R. Hill, Pyrolysis Mechanisms and Weathering Phenomena
in Rocky Mountain Coals, ACS Reprints (Div. of Fuel Chem.) Vol.
29, No. 5, 1984, pp. 166-177.
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